Neonatal Information

1 Timing Information

2 Total Bilirubin

3 Gestational Age

AAP 2022 & NICE CG98: applies to infants ≥ 35 weeks gestation

4 Neurotoxicity Risk Factors Optional

Neurotoxicity Risk (AAP 2022)
Clinical Risk (NICE CG98)
ppm

5 Phototherapy status

BiliTool.Vn — Dual Protocol Engine

Combined AAP 2022 & NICE CG98 — Dual-protocol neonatal jaundice evaluation system

Enter neonatal details on the left to receive automated bilirubin evaluations. The system calculates thresholds under both guidelines in parallel and recommends the most conservative (safest) intervention threshold.

AAP 2022 — Pediatrics 150(3):e2022058859

  • Phototherapy/Exchange thresholds sorted by GA (35–40 weeks) and neurotoxicity risks
  • Escalation of Care when bilirubin is within 2.0 mg/dL of the exchange threshold
  • Rapid rate of rise: ≥ 0.3 mg/dL/h (<24h) or ≥ 0.2 mg/dL/h (≥24h)

NICE CG98 — Jaundice in newborn babies under 28 days

  • Threshold tables by age (hours) for infants ≥38w + formula interpolation for preterm infants
  • Kernicterus risk assessment (TSB >340 µmol/L, rate of rise >8.5 µmol/L/h)
  • Prolonged jaundice detection (≥37w: >14 days; <37w: >21 days)
  • IVIG indications (Rh/ABO hemolytic disease + rate of rise >8.5 µmol/L/h)
  • Phototherapy stopping criteria (TSB ≥50 µmol/L below threshold) + rebound check at 12-18h

Safety Principle:

  • The algorithm always selects the lower (safer) threshold between AAP 2022 and NICE CG98
  • Results indicate the decisive protocol (AAP 2022 or NICE CG98) for clinical transparency
  • Full support for both mg/dL (US) and µmol/L (International)
  • Comprehensive assessment: neurotoxicity risks (AAP) + clinical risk factors (NICE)
AAP 2022 Protocol NICE CG98 Guideline